Whole genome sequencing is often approached by a shotgun sequencing technique in which large genomes are:

Question

Quizplus · Accepted Answer

Shotgun sequencing involves randomly digesting a genome into small fragments, sequencing those fragments, and then assembling the overlapping sequences in the correct order. This is typically done using computers to align the sequences and fill in any gaps to create the complete genome sequence. Option A accurately describes this process. Option B is incorrect because the genome is not digested in only a few specific spots. Option C and D are incorrect because the overlapping sequences are assembled in order, not by size.

Whole Genome Sequencing Is Often Approached by a Shotgun Sequencing