The appearance of abnormal metabolites in the urine due to a defect categorized as an "overflow type" may be caused by all of the following except:
A) Inborn errors of metabolism
B) Serum concentrations exceeding the Tm
C) Abnormalities in the tubular reabsorption mechanism
D) Disruption of normal enzyme function by exposure to toxic substances

Question

Quizplus · Accepted Answer

The "overflow type" of abnormal metabolite appearance in urine is characterized by the presence of substances in the blood at concentrations exceeding their renal threshold (Tm) or due to inborn errors of metabolism and disruptions caused by toxic substances, leading to abnormal metabolites being produced and excreted. It does not involve abnormalities in the tubular reabsorption mechanism, which relates to a different type of defect where substances that are normally reabsorbed by the renal tubules are instead excreted in the urine.

The Appearance of Abnormal Metabolites in the Urine Due to a Defect