Which of the following is not true of human FoxP2?
A) It encodes a protein with two amino acids unique to humans among extant animals.
B) It possesses a base substitution in an intron that is likely to regulate its expression.
C) It had the same amino acid sequence in our closest relatives, the Neanderthals and the Denisovans.
D) It can substitute for all functions of mouse FoxP2.
E) None of the above

Question

Quizplus · Accepted Answer

The two human FoxP2 amino acid substitutions were present in both the Neanderthals and the Denisovans but not in any other species alive today. These changes seem to alter its activity: although human FoxP2 can substitute for mouse FoxP2 in many contexts, knock-in animals still have abnormal striatal neuronal morphology and ultrasonic vocalization patterns. There is also a base change in intron 8 that alters transcriptional enhancement by POU3F2 in vitro.

Which of the Following Is Not True of Human FoxP2