How does Figure contribute to the evidence that the Aβ oligomer interferes with loss of memory in Alzheimer's disease? Figure Q11-2
A) The experiment showed that the Aβ oligomer induced long-term depression, suggesting it could reduce learning and memory.
B) The experiment showed that the Aβ oligomer blocked synaptic transmission, suggesting it could block memory formation.
C) The experiment showed that the Aβ oligomer blocked memory formation while keeping learning intact.
D) The experiment showed that the Aβ oligomer blocked long-term potentiation suggesting that it could block learning and memory.

Question

How does Figure  contribute to the evidence that the Aβ oligomer interferes with loss of memory in Alzheimer's disease?  Figure Q11-2
A) The experiment showed that the Aβ oligomer induced long-term depression, suggesting it could reduce learning and memory. 
B) The experiment showed that the Aβ oligomer blocked synaptic transmission, suggesting it could block memory formation. 
C) The experiment showed that the Aβ oligomer blocked memory formation while keeping learning intact. 
D) The experiment showed that the Aβ oligomer blocked long-term potentiation suggesting that it could block learning and memory.

Quizplus · Accepted Answer

In this figure, HFS (high frequency stimulation) was given to the perforant path to induce LTP in the dentate gyrus neurons in control hippocampal slices. When the Aβ oligomer was applied to the slice and the HFS was given LTP was not elicited. As LTP is a cellular mechanism for memory, this also suggests that the Aβ oligomer can block memory.

How Does Figure Contribute to the Evidence That the Aβ