How is the Aβ protein produced? Include the name of the precursor protein.
A) The APP protein is cleaved by α-secretase, which is then cleaved by β-secretase.
B) The APP protein is cleaved by β-secretase and then by α-secretase.
C) The APP protein is cleaved by α-secretase and then γ-secretase.
D) The APP protein is cleaved by β-secretase and then γ-secretase.

Question

Quizplus · Accepted Answer

The Aβ protein comes from the β-secretase, which cleaves the APP-β protein from the APP protein. The γ-secretase then cleaves the Aβ protein from the remaining Cterminal of the APP protein. The α-secretase cleaves the APP protein in the middle of the Aβ protein.

How Is the Aβ Protein Produced? Include the Name of the Precursor