Why was the postsynaptic CA1 neuron voltage clamped to +30 mV? Select all that apply. A) To stimulate insertion of AMPA receptors into the postsynaptic membrane B) To move NMDA receptors into the synapse from an extrasynaptic site C) To cause coordination between the pre- and postsynaptic neuron D) To increase conductance of the NMDAR by removing the Mg²⁺ block E) To stimulate AMPA receptors, which in turn activate NMDA Rs

Question

Quizplus · Accepted Answer

At rest, -60 mV, the NMDARs are blocked with Mg²⁺. When the postsynaptic cell was depolarized to +30 mV this removed the Mg²⁺ block, which resulted in the measured postsynaptic response.

Why Was the Postsynaptic CA1 Neuron Voltage Clamped to +30