In adult neurons, there is a higher concentration of chloride outside the cell than inside the cell. During development intracellular chloride concentrations are much higher such that GABA causes excitation of the postsynaptic neuron. Why could changing the Cl^- concentration result in excitation? A) E_Cl is now action potential threshold. B) E_Cl is now

Question

In adult neurons, there is a higher concentration of chloride outside the cell than inside the cell. During development intracellular chloride concentrations are much higher such that GABA causes excitation of the postsynaptic neuron. Why could changing the Cl^- concentration result in excitation? A) E_Cl is now > action potential threshold. B) E_Cl is now < action potential threshold. C) There is a smaller Ca²⁺ conductance. D) Higher concentrations of Cl^- modulate the GABA_R single channel conductance.

Quizplus · Accepted Answer

Changing the ion concentration inside and outside the neuron will change the equilibrium potential of the ion. If the E_Cl is about the action potential threshold, activation of those channels will excite the neuron.

In Adult Neurons, There Is a Higher Concentration of Chloride