Study the Mutations Described Below and Determine Which One Is

Study the mutations described below and determine which one is most likely to lead to cancer.

A) A mutation in the Ras protein increases its affinity for GDP.
B) A mutation in the Ras protein that prevents GTP hydrolysis.
C) A mutation in a receptor protein that decreases its affinity for a growth factor.
D) A mutation in a transcription factor that prevents it from binding to the DNA to transcribe genes that promote cell division.
E) All of these mutations might lead to cancer.