Study the Mutations Below and Determine Which Is the Most

Study the mutations below and determine which is the most likely to lead to cancer.

A) A mutation that increases the affinity of Rb for E2F
B) A mutation that prevents the phosphorylation of Rb
C) A mutation that prevents E2F from associating with DNA
D) A mutation that caused the cyclin-dependent kinase that interacts with Rb to be overactive
E) All of these are mutations that would lead to cancer