A new aminoglycoside antibiotic is developed to treat resistent pseudomonas . The volume of distribution of the drug is measured in a group of volunteers and is determined to be 4.5 L. This new drug is most likely to have which of the following properties?

Question

A new aminoglycoside antibiotic is developed to treat resistent pseudomonas . The volume of distribution of the drug is measured in a group of volunteers and is determined to be 4.5 L.  This new drug is most likely to have which of the following properties?

Quizplus · Accepted Answer

Eductional Objective: Characteristics of a drug such as high molecular weight, high plasma protein binding, high charge, and hydrophilicity tend to trap the drug in the plasma compartment resulting in a low Vd (3-5 L).

A New Aminoglycoside Antibiotic Is Developed to Treat Resistent Pseudomonas