A researcher is deveolping a new medication to treat a severe kidney infection, which is desired to be non-renal clearance to decrease the side effect on the kidenys at the same time to be metabolised and cleared in the liver hepatic metabolism. Which of the following characteristics should the antibiotic also have if hepatic metabolism and clearance is desired?

Question

Quizplus · Accepted Answer

Eductional Objective: While the kidney is the primary site of elimination of most drugs, the liver is the main site of biotransformation of these agents in preparation for elimination. Drugs that are more lipophilic (high Vd, good penetration into CNS) are preferentially processed by the liver into more polar compounds for easier elimination in the bile and urine. Liver disease (e.g., cirrhosis) or the concomitant use of other drugs may limit or enhance the clearance of drugs metabolized in the liver.

A Researcher Is Deveolping a New Medication to Treat a Severe