A 35-year-old lady who is receiving bipolar illness treatment complains of having a lot of thirst and urinating often. Every night, she wakes up three to four times to go to the bathroom. Following an 8-hour fast without food and liquids, a urinalysis reveals the following: 11ec160b 3c6e d2f8 9249 f57b157fe8f1 MD0001 00 Which of the following nephron components in this patient is most likely damaged?

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Quizplus · Accepted Answer

Eductional Objective: After 8 hours of water restriction, this patient exhibits polydipsia, polyuria, and an abnormally low urine specific gravity. Although it is within the usual range, the specific gravity of the urine should be greater (i.e. > 1.010) following water deprivation since the pee is more concentrated.
These results are strongly supportive of lithium-induced nephrogenic diabetic insipidus given her mental background. Lithium therapy decreases the kidneys' capacity to concentrate urine chiefly through inhibiting vasopressin's (an antidiuretic hormone) activity in the collecting tubules and ducts. Lithium-induced nephrogenic diabetic insipidus often goes away after the medication is stopped. However, after years of continued usage, disability may become irreversible.

A 35-Year-Old Lady Who Is Receiving Bipolar Illness Treatment Complains