Breast cancer is diagnosed in a 55-year-old woman, who has a breast-sparing mastectomy. The tumor margin was free of invasion, and a sentinel axillary lymph node biopsy revealed no evidence of nodal metastasis. The tumor expressed estrogen and progesterone receptors but not HER-2. Tamoxifen is prescribed after a discussion of treatment options with the patient. She has hot flashes that come and go in waves while taking this medication, which has a significant impact on her sleep. following conditions is the patient also likely to experience as a result of this therapy?

Question

Quizplus · Accepted Answer

Eductional Objective: Selective estrogen receptor modulators (e.g., tamoxifen, raloxifene) compete with estrogen to bind to estrogen receptors. Depending on the tissue, they can have agonist or antagonist effects. Tamoxifen causes endometrial hyperplasia and cancer by having an estrogenic effect on the uterus.

Breast Cancer Is Diagnosed in a 55-Year-Old Woman, Who Has