Researchers create a cohort of experimental rats with anthracycline-induced heart failure to study the impact of heart failure on the pharmacokinetics of anti-diabetic drugs. Then, a dosage of metformin is given orally to the test animals, and blood levels are tracked over time. The experiment is repeated in control animals with healthy hearts, and the outcomes are displayed below: Which of the following best explains the change in serum metformin levels seen in the experimental animals?

Question

Researchers create a cohort of experimental rats with anthracycline-induced heart failure to study the impact of heart failure on the pharmacokinetics of anti-diabetic drugs. Then, a dosage of metformin is given orally to the test animals, and blood levels are tracked over time. The experiment is repeated in control animals with healthy hearts, and the outcomes are displayed below:  Which of the following best explains the change in serum metformin levels seen in the experimental animals?

Quizplus · Accepted Answer

Eductional Objective: Reduced liver and renal perfusion from heart failure affects medication clearance. Due to the fact that metformin is eliminated unaltered by the kidney, people who have considerable renal insufficiency from heart failure or other conditions (such as chronic kidney disease) are more likely to have harmful effects (eg, lactic acidosis).

Researchers Create a Cohort of Experimental Rats with Anthracycline-Induced Heart