Researchers are conducting an experiment to evaluate genetic diversity in medication biotransformation. Four hours after administering a set dosage of isoniazid to a group of volunteers, the plasma drug concentration is assessed. These participants' plasma drug concentrations are distributed as follows. Variation of which of the following processes provides the best explanation for the shaded area of the curve?

Question

Researchers are conducting an experiment to evaluate genetic diversity in medication biotransformation. Four hours after administering a set dosage of isoniazid to a group of volunteers, the plasma drug concentration is assessed. These participants' plasma drug concentrations are distributed as follows.  Variation of which of the following processes provides the best explanation for the shaded area of the curve?

Quizplus · Accepted Answer

Eductional Objective: Acetylation is used to break down isoniazid. Whether a patient is a "fast" or "slow" acetylator genetically determines how quickly they can acetylate medications. A bimodal distribution of the rate of isoniazid metabolism emerges from the coexistence of rapid and slow acetylators in the same population. Slow acetylators are more likely to experience negative side effects.

Researchers Are Conducting an Experiment to Evaluate Genetic Diversity in Medication