A 50-year-old man is being evaluated in the office for medication adujstment due to recent finiding in last echocardiogram. He has a history of systolic heart failure. He reports a new feeling fatigue after short distances. The physician decides to add spironolactone to the treatment regimen. The addition of this medication is most likely to cause a decrease in which of the following?

Question

A 50-year-old man is being evaluated in the office for medication adujstment due to recent finiding in last echocardiogram. He has a history of systolic heart failure. He reports a new feeling fatigue after short distances. The physician decides to add spironolactone to the treatment regimen.  The addition of this medication is most likely to cause a decrease in which of the following?

Quizplus · Accepted Answer

Eductional Objective: Aldosterone acts on the principal and intercalated cells of the renal collecting tubules to increase resorption of sodium and water and increase excretion of potassium and hydrogen ions.  Aldosterone receptor antagonists (eg, spironolactone, eplerenone) inhibit these effects.

A 50-Year-Old Man Is Being Evaluated in the Office for Medication