Question 1

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
-A T cell adhesion molecule that binds to fibronectin in extracellular matrices

Accepted Answer

VLA-4 (a4b1) is an integrin expressed on T cells
In addition to binding to VCAM-1 on endothelial cells, VLA-4 also binds fibronectin in the extracellular matrix
In this way, VLA-4 contributes to movement and retention of T cells in the extravascular space.

Question 2

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
-A membrane molecule expressed on T cells that promotes migration of TH2 cells into certain inflammatory sites

Accepted Answer

CCR4 is one of the chemokine receptors that is more abundantly expressed on TH2 cells than other T cell subsets
CCR4 binds the chemokines CCL17 and CCL22.

Question 3

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
-This intracellular signaling molecule and transcription factor is activated by IL-12.

Accepted Answer

Interleukin (IL)-12 binding to its receptors on T cells and natural killer (NK) cells activates the Janus kinase Tyk2, which phosphorylates and activates STAT4
The functional responses of cells to IL-12 are dependent on STAT4-dependent gene transcription
Therefore, TH1 differentiation, which requires IL-12 stimulation of naive T cells, is dependent on STAT4.

Question 4

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
-This membrane molecule is expressed on the surface of activated TH1 cells and promotes macrophage activation.

Accepted Answer

CD40L (CD154), a member of the tumor necrosis factor (TNF) family of proteins, is expressed on TH1 cell after antigen-induced activation and binds to CD40, a member of the TNF receptor family, on macrophages
The signals generated by CD40 promote macrophage activation as well as B cell differentiation
Interferon-g, also produced by helper T cells, synergizes with CD40 ligand in activating macrophages.

Question 5

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
-Mediates naive CD4+ T cell migration into lymph nodes

Accepted Answer

L-selectin is expressed abundantly on naive T cells, but not effector T cells, and binds to peripheral lymph node addressin (PNAd) on high endothelial venules in lymph nodes
This adhesive interaction is required for naive T cell migration from blood into lymph nodes, a first step in the initiation of cell-mediated immune responses.

Question 6

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
-This intracellular signaling molecule and transcription factor is required for differentiation of TH2 cells and for responses of other cells to TH2 cells.

Accepted Answer

STAT6 is an intracellular signaling molecule that is activated by interleukin (IL)-4, via JAK3 and JAK4
IL-4 activation of STAT6 is required for the differentiation of naive T cells into the TH2 phenotype, as well as for the effects of IL-4 on other cell types, such as isotype switching to IgE in B cells.

Question 7

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
-Induces expression of endothelial selectins and Ig superfamily adhesion molecules, promoting effector T cell migration into inflammatory sites

Accepted Answer

Tumor necrosis factor (TNF) is a cytokine secreted by mononuclear phagocytes as part of the innate immune response
One important function of TNF is to induce adhesion molecule expression on nearby vascular endothelial cells, including E-selectin, ICAM-1, and VCAM-1
These adhesion molecules contribute to the recruitment of various inflammatory cells.

Question 8

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
-A ligand on a subset of T cells that binds to E-selectin

Accepted Answer

CLA is an E-selectin ligand expressed on a subset of effector and memory CD4⁺ and CD8⁺ T lymphocytes; it promotes the migration of these T cells into the skin.

Question 9

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list.
-This product of TH2 cells promotes immunity to helminthic infections.

Accepted Answer

Interleukin (IL)-5 is a cytokine produced by TH2 cells that stimulates production of eosinophils in the bone marrow and promotes eosinophil activation
Eosinophil granules contain molecules, such as major basic protein, that are particularly toxic to helminths.

Question 10

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L).
-Mediates homing of a subset of T cells into the intestinal mucosa

Accepted Answer

The integrin a4b7 is expressed on a subset of effector and memory T cells, which home to intestinal mucosa
a4b7 binds to mucosal addressin cell adhesion molecule (MAdCAM) on endothelial cells in the intestine.

Quiz 6: Effector Mechanisms of Cell-Mediated Immunity

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L) . -A T cell adhesion molecule that binds to fibronectin in extracellular matrices

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L) . -A membrane molecule expressed on T cells that promotes migration of TH2 cells into certain inflammatory sites

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list. -This intracellular signaling molecule and transcription factor is activated by IL-12.

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list. -This membrane molecule is expressed on the surface of activated TH1 cells and promotes macrophage activation.

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L) . -Mediates naive CD4+ T cell migration into lymph nodes

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list. -This intracellular signaling molecule and transcription factor is required for differentiation of TH2 cells and for responses of other cells to TH2 cells.

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L) . -Induces expression of endothelial selectins and Ig superfamily adhesion molecules, promoting effector T cell migration into inflammatory sites

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L) . -A ligand on a subset of T cells that binds to E-selectin

Match descriptions of cell-mediated immune responses in questions , with the appropriate molecule (A-H) from the following list. -This product of TH2 cells promotes immunity to helminthic infections.

For each of the descriptions in questions , select the molecule involved in T cell traffic (A-L) . -Mediates homing of a subset of T cells into the intestinal mucosa