M12332The formation of purine deoxyribonucleotides from the corresponding ribonucleotides

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The formation of purine deoxyribonucleotides from the corresponding ribonucleotides involves the removal of the oxygen atom attached to the 2'-carbon of the ribose sugar at the nucleoside diphosphate level, resulting in the formation of the corresponding deoxyribonucleotide. This process is catalyzed by ribonucleotide reductase, which requires a thioredoxin-like protein to reduce a disulfide bond in the enzyme with tetrahydrofolic acid serving as the electron donor. The conversion of UDP to dUDP is not involved in this process, and the level of ribonucleoside monophosphates in the cell does not directly regulate ribonucleotide reductase activity. While important for DNA replication, this process is also key for other biosynthetic pathways involving purine deoxyribonucleotides.

M12332The Formation of Purine Deoxyribonucleotides from the Corresponding Ribonucleotides