M12321Absence or inhibition of the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT) results in increased production of

Question

Quizplus · Accepted Answer

Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) is an enzyme that plays a key role in the salvage pathway of purine metabolism, where purine nucleotides are regenerated from their derivatives. In the absence or inhibition of HGPRT, the salvage pathway is disrupted, leading to increased production of uric acid, which is the end product of purine metabolism. This can result in conditions such as gout or Lesch-Nyhan syndrome, which are characterized by high levels of uric acid in the body. Choices B, C, D, and E are incorrect as they are not directly related to the function of HGPRT.

M12321Absence or Inhibition of the Enzyme Hypoxanthine-Guanine Phosphoribosyl Transferase (HGPRT)