The action of methotrexate in inhibiting cell growth is based on its structural similarity to

Question

Quizplus · Accepted Answer

Methotrexate works by inhibiting the enzyme dihydrofolate reductase (DHFR), which is responsible for converting dihydrofolate to tetrahydrofolate, a necessary cofactor in the synthesis of nucleic acids. Methotrexate has a structural similarity to dihydrofolate and thus competitively inhibits DHFR, leading to decreased DNA synthesis and cell growth.

The Action of Methotrexate in Inhibiting Cell Growth Is Based