Citrate synthase and the NAD⁺-specific isocitrate dehydrogenase are two key regulatory enzymes of the citric acid cycle. These enzymes are inhibited by:

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Citrate synthase and isocitrate dehydrogenase are both inhibited by high levels of ATP and NADH, which indicate that energy needs are being met and the citric acid cycle can slow down to prevent overproduction of ATP. Acetyl-CoA and fructose 6-phosphate are not known inhibitors of these enzymes, and while AMP can activate certain enzymes in the citric acid cycle, it is not a direct inhibitor of citrate synthase or isocitrate dehydrogenase.

Citrate Synthase and the NAD+-Specific Isocitrate Dehydrogenase Are Two Key

Citrate Synthase and the NAD⁺-Specific Isocitrate Dehydrogenase Are Two Key