In experiments in which rat embryo fibroblasts were transfected with suspected oncogenes,introduction of which of the following genes transformed the cells?
A)Myc alone
B)H-Ras alone
C)E1A alone
D)Both Myc and E1A together
E)Both Myc and H-Ras together

Question

Quizplus · Accepted Answer

The introduction of both Myc and H-Ras together transformed the cells. Alone, Myc and H-Ras can promote cell growth, but they don't transform the cells into cancer cells. However, when they are introduced together, they act synergistically and confer transforming activity to the cells. E1A alone can induce cell cycle re-entry and promote cell growth but doesn't have transforming activity. Myc alone can promote cell growth but doesn't have transforming activity. H-Ras alone can promote cell growth but doesn't have transforming activity.

In Experiments in Which Rat Embryo Fibroblasts Were Transfected with Suspected