You are studying cancer cells,and hypothesize that you have found a previously unidentified tumor suppressor gene.Which of the following results would support your hypothesis?
A) You have found loss of heterozygosity in the locus containing your gene in a number of human lung cancer samples.
B) You have identified a gain-of-function mutation in this gene that results in the transformation of normal cells.
C) Functional analysis has revealed that the wild-type form of the gene that you have identified serves to drive proliferation.
D) B and C.
E) None of the above.
Correct Answer:
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Q1: Which of the following statements about NF1
Q2: Which of the following genes is NOT
Q3: Sporadic cases of retinoblastoma require
A)One inactivating somatic
Q4: When a normal cell and a cancer
Q5: The APC protein
A)Is essential for degrading β-catenin.
B)Causes
Q6: Single nucleotide polymorphism markers SNPs)are found approximately
Q8: Which of the following is TRUE of
Q9: You are studying a cell line in
Q10: HIF-1α levels may go up when
A)Oxygen conditions
Q11: Inactivation of tumor suppressor genes can occur
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