The extent to which an individual's T cells respond to allogeneic HLA expressed on irradiated donor cells can be measured in vitro using _____.

Question

Quizplus · Accepted Answer

The mixed lymphocyte reaction (MLR) measures the extent to which an individual's T cells respond to allogeneic HLA expressed on irradiated donor cells. In this assay, T cells from the individual are mixed with irradiated cells from a different HLA type individual and their proliferation is measured. A high level of proliferation indicates a strong immune response against the foreign cells, while a low level of proliferation indicates immune tolerance. The other options listed (cross-match test, superantigen recognition test, transfusion effect assay, and panel reactive antibody test) are not used to measure T cell response to allogeneic HLA expressed on irradiated donor cells.

The Extent to Which an Individual's T Cells Respond to Allogeneic