As the number of expressed MHC isoforms in the thymus increases beyond a certain value,the T-cell repertoire _____.

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Quizplus · Accepted Answer

As the number of expressed MHC isoforms in the thymus increases, the T-cell repertoire becomes smaller because T-cells undergo positive and negative selection processes in the thymus, which are based on their ability to recognize MHC molecules. With more MHC isoforms, there are stricter criteria for T-cell selection, leading to a smaller repertoire of T-cells that can successfully mature.

As the Number of Expressed MHC Isoforms in the Thymus