Patients Who Have Previously Received a Blood Transfusion That Has

Patients who have previously received a blood transfusion that has HLA-DR allotypes in common with their kidney transplant are _____.

A) less likely to reject the graft owing to the presence of regulatory CD4 T cells
B) more likely to reject the graft owing to the presence of HLA alloantibodies
C) less likely to reject the graft owing to negative selection of alloreactive T-cell clones
D) at risk of developing a hyperacute rejection
E) at risk of developing graft-versus-host disease.