Which of the following statements about Notch 1 is correct? (Select all that apply.)
A) Notch 1 is expressed on thymic epithelial cells.
B) In the absence of Notch 1 expression,T cells can complete their differentiation.
C) Notch 1 is to T-cell development as Pax-5 is to B-cell development.
D) Notch 1 contains two distinct domains,one of which is proteolytically cleaved and becomes a transcription factor in the nucleus.
E) The extracellular domain of Notch 1 must interact with a ligand on thymic epithelium to initiate cleavage and separation of the Notch 1 extracellular and intracellular domains.
Correct Answer:
Verified
Q1: Which of the following statements regarding positive
Q2: Genetic deficiencies in all of the following
Q4: Which of the following processes is not
Q5: If a double-negative thymocyte has just completed
Q6: Thymocytes that are not positively selected
A)undergo genetic
Q7: Which of the following is mismatched:
A)double-negative CD3-
Q8: Which of the following statements are true
Q9: Which of the following is the first
Q10: In which of the following ways does
Q11: _ of thymocytes is necessary to produce
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