Describe the six functionally distinct phases of B-cell development.

Question

Quizplus · Accepted Answer

The Answer is 1)Repertoire assembly: Bone marrow expression of diverse B-cell receptors. (2)Negative selection: Modification,elimination or inactivation of autoreactive B cells. (3)Positive selection: Selection of a small subset of immature B cells to become mature B cells in secondary lymphoid organs. (4)Searching for infection: Patrolling for infectious material by recirculating continuously between lymph,blood and secondary lymphoid organ compartments. (5)Finding infection: B cells become activated by antigen in secondary lymphoid tissues and then undergo clonal expansion. (6)Attacking infection: B cells differentiate into plasma cells and memory cells in secondary lymphoid tissues.

Describe the Six Functionally Distinct Phases of B-Cell Development