A knock- out mouse is made with respect to the PFKL gene,and this mouse is now described as which of the following?
A)a gain- of- function PFKL mouse
B)an enhancement- of- function PFKL mouse
C)a loss- of- function PFKL mouse
D)a retention- of- function PFKL mouse

Question

Quizplus · Accepted Answer

Knock-out mice are used to study the function of a specific gene by removing or "knocking out" its expression. In this case, the knock-out mouse is made with respect to the PFKL gene, so its function is lost or disrupted. Therefore, the correct answer is C - a loss-of-function PFKL mouse.

A Knock- Out Mouse Is Made with Respect to the PFKL