Neoplasms are made up of a population of identical cells or a clone of cells. When identified, the clone can lead to the discovery of a lymphoid malignancy or other lymphoproliferative disorder. Clonality be detected by:
A) The uniform expression of one immunoglobulin light chain
B) A mixture of cells with either kappa or lambda light chains
C) A surface immunoglobulin detection
D) The bright intensity of all monoclonal markers

Question

Quizplus · Accepted Answer

The uniform expression of one immunoglobulin light chain indicates clonality of the neoplasm. B and C are incorrect as a mixture of light chains and surface immunoglobulin detection can occur in both monoclonal and polyclonal populations. D is incorrect as the intensity of monoclonal markers can vary between different clones.

Neoplasms Are Made Up of a Population of Identical Cells