In diagnosing PNH, which of the following assays is most sensitive to its detection?
A) GPI anchor phenotype
B) Ham test
C) Sucrose lysis test
D) Osmotic fragility test

Question

Quizplus · Accepted Answer

The GPI anchor phenotype assay is the most sensitive to the detection of PNH as it identifies the absence of GPI-linked proteins on the surface of red blood cells. This assay is considered the gold standard for PNH diagnosis. The Ham test, sucrose lysis test, and osmotic fragility test are also used in PNH diagnosis but are less sensitive and specific compared to the GPI anchor phenotype assay.

In Diagnosing PNH, Which of the Following Assays Is Most