A laboratory professional reviewed the CBC of a patient who had a WBC count of 5 × 10³/μL with 32% blasts present. Follow up testing with cytogenetics revealed t(15;17)(q22;q12). Which of the following is a likely diagnosis for the patient?

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Quizplus · Accepted Answer

The abnormal WBC count with a significantly high percentage of blasts suggests a myeloid neoplasm. The presence of t(15;17)(q22;q12) is characteristic of acute promyelocytic leukemia (APL). MDS and CLL typically do not have high blast counts, and while MPNs can have elevated WBC counts, they do not typically show this specific chromosomal abnormality.

A Laboratory Professional Reviewed the CBC of a Patient Who