An acute leukemia patient presents with blast morphology that is of neutrophil lineage with Auer rods and pseudo-Pelger-Huët nuclei, myeloperoxidase, and Sudan Black B. Cytogenetic analysis reveals a t(8;21)(q22;q22) translocation in the majority of the blasts. Which classification of AML best fits this morphology, immunophenotyping, and cytochemistry?

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The morphology of neutrophil lineage blasts with Auer rods and pseudo-Pelger-Huët nuclei, along with myeloperoxidase and Sudan Black B positivity, is consistent with AML with recurrent genetic abnormalities. The presence of t(8;21)(q22;q22) translocation further supports this classification, which is also known as AML with maturation (French-American-British classification M2 subtype).

An Acute Leukemia Patient Presents with Blast Morphology That Is