Which, If Any, of the Following Statements Is False

Which, if any, of the following statements is false?

A) Gain-of-function mutations are often missense mutations.
B) A missense mutation that has a dominant-negative effect can often produce a greater loss of protein function than a null mutation.
C) Pathogenic gain-of-function and loss-of-function mutations in the same gene produce different phenotypes .
D) A mutant protein that antagonizes the wild type protein produced from the normal allele is known as a hypomorph.