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Question 8

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Fill in the blanks using numbers.
Depending on our ethnic background, each of us carries about ___1___or so mutations that would be expected to result in loss of gene function (with an average of ___2____ genes that are homozygously inactivated), plus about ____3____ missense variants that severely damage protein structure. When you factor in additional mutations in noncoding DNA, a normal person might be expected to have a total of over ____4____ damaging DNA variants.

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