A compound is added to a cell and dihydrofolate reductase activity is reduced. If this compound is , it can be predicted that a similar result would be seen if were added instead. A) methotrexate; aminopterin B) methotrexate; raltitrexed C) aminopterin; raltitrexed D) aminopterin; fluorodeoxyuridine-5 ^' -monophosphate

Question

Quizplus · Accepted Answer

Methotrexate and aminopterin are both inhibitors of dihydrofolate reductase, so if one reduces activity, it is likely that the other would have a similar effect. Raltitrexed is also a dihydrofolate reductase inhibitor but works through a different mechanism, so it is not as likely to have the same effect as methotrexate or aminopterin. Fluorodeoxyuridine-5-monophosphate is not a dihydrofolate reductase inhibitor, so it would not have the same effect.

A Compound Is Added to a Cell and Dihydrofolate Reductase