If a mutation occurred in SODD that prohibited its interaction with the DD of TNF receptor, the TNF receptor would
A) no longer form a trimer.
B) no longer be able to release TNF-$\alpha$.
C) bind TRADD, even in the absence of TNF-$\alpha$.
D) bind NF$\kappa$B, even in the absence of TNF-$\alpha$.

Question

Quizplus · Accepted Answer

SODD (Silencer of Death Domains) normally binds to the death domain (DD) of the TNF receptor, preventing unwanted signaling. If SODD cannot interact with the TNF receptor's DD, the receptor could prematurely bind TRADD (TNF receptor-associated death domain protein), even without the presence of its ligand (TNF-alpha), leading to downstream signaling events.

If a Mutation Occurred in SODD That Prohibited Its Interaction α\alphaα

If a Mutation Occurred in SODD That Prohibited Its Interaction $\alpha$