Consider a mutation in procaspase 3 that changes Asp28 to an amino acid that is no longer a substrate for autocleavage.This mutant would
A) no longer be cleaved by caspase 8.
B) no longer obtain a quaternary structure.
C) be partially activated.
D) be fully activated.

Question

Quizplus · Accepted Answer

Autocleavage of procaspase 3 at Asp28 is necessary for its full activation. Therefore, a mutation that prevents this cleavage site from being recognized would result in partial activation. The mutant procaspase 3 would still be cleaved by caspase 8, and it could still form a quaternary structure. However, it would not be fully activated since autocleavage at Asp28 is a crucial step in its activation process.

Consider a Mutation in Procaspase 3 That Changes Asp28 to an Amino