Below is shown a short sequence of a protein.Which of the following domains would most likely bind this sequence?
A) SH2
B) SH3
C) SH2a
D) SHP

Question

Below is shown a short sequence of a protein.Which of the following domains would most likely bind this sequence? 
A) SH2 
B) SH3 
C) SH2a 
D) SHP

Quizplus · Accepted Answer

The amino acid sequence shown is a proline-rich sequence, which is a common binding site for the SH3 domain. SH2 domains generally bind to tyrosine-phosphorylated residues, and there are no tyrosine residues in the sequence. SH2a and SHP are not commonly found domains and are not known to specifically bind to proline-rich sequences.

Below Is Shown a Short Sequence of a Protein