Which of the following is true of sickle cell anemia?
A) It is a dominant genetic disease.
B) It is caused by a mutation in the $\alpha$-globin gene.
C) It is caused by an amino acid substitution in the F helix.
D) It results in a hemoglobin that contains a hydrophobic amino acid on the surface.

Question

Quizplus · Accepted Answer

Sickle cell anemia results from a mutation in the beta-globin gene, leading to a substitution of valine for glutamic acid at the sixth position of the beta chain, creating a hydrophobic patch on the hemoglobin surface.

Which of the Following Is True of Sickle Cell Anemia α\alphaα

Which of the Following Is True of Sickle Cell Anemia $\alpha$