Which of the following may result from a His143 $\rightarrow$ Ala143 mutation in adult hemoglobin? A) decreased CO₂ transport efficiency B) increased oxygen transport efficiency C) reduced affinity for 2,3-BPG D) sickle cell anemia

Question

Quizplus · Accepted Answer

The His143 residue plays a crucial role in forming a salt bridge with the 2,3-BPG molecule in adult hemoglobin, reducing its affinity for oxygen. The His143 F1F1F1S1F1F1F10 Ala143 mutation would disrupt this interaction, resulting in reduced affinity for 2,3-BPG, which can lead to decreased oxygen transport efficiency. This mutation is not associated with sickle cell anemia.

Which of the Following May Result from a His143 →\rightarrow→ Ala143 Mutation in Adult Hemoglobin? A) Decreased CO2 Transport Efficiency

Which of the Following May Result from a His143 $\rightarrow$ Ala143 Mutation in Adult Hemoglobin?
A) Decreased CO₂ Transport Efficiency