An osmotic fragility test is performed on a patient's sample.Initial hemolysis occurs at 0.75% NaCl and complete hemolysis occurs at 0.50% NaCl.These results are indicative of which of the following disorders?

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Quizplus · Accepted Answer

Hereditary spherocytosis is characterized by increased osmotic fragility of red blood cells. In this condition, the cells are more prone to hemolysis at higher concentrations of NaCl (such as 0.75%) compared to normal cells, and complete hemolysis occurs at lower NaCl concentrations (such as 0.50%), indicating a heightened sensitivity of the red blood cells to osmotic stress.

An Osmotic Fragility Test Is Performed on a Patient's Sample