Huntington disease is caused by expansion of the trinucleotide repeat region of the HD gene that results in the production of a Huntingtin protein with an expanded number of glutamines.An animal model with most features of this syndrome could be created by
A)adding a transgene containing a disease-causing mutant allele of the HD gene to a mouse or primate genome.
B)adding a transgene containing a wild-type copy of the HD gene to a mouse or primate genome.
C)knocking out both copies of the HD gene from a mouse or primate genome.
D)knocking out one copy of the HD gene from a mouse or primate genome.

Question

Quizplus · Accepted Answer

Adding a transgene containing a disease-causing mutant allele of the HD gene to a mouse or primate genome would mimic the human condition by introducing the same type of genetic mutation that causes Huntington disease, leading to the production of the mutant Huntingtin protein with an expanded number of glutamines.

Huntington Disease Is Caused by Expansion of the Trinucleotide Repeat