Linkage between a gene of interest and a DNA marker is being studied. A mating results in 19 parental and 1 recombinant offspring.
-What is the maximum Lod score for linkage at this locus?
A)0.22
B)1.1
C)6.3
D)11

Question

Quizplus · Accepted Answer

The maximum Lod score for linkage at this locus can be calculated using the formula: Lod = log10[(1 - r)^n / (0.5)^n], where r is the recombination fraction and n is the total number of offspring. In this case, with 19 parental and 1 recombinant offspring, r = 1/20 = 0.05, and n = 20. Plugging these values into the formula gives a Lod score of approximately 6.3, indicating strong evidence for linkage.

Linkage Between a Gene of Interest and a DNA Marker