A Scientist Edits a Mammalian Gene by Changing a Single

A scientist edits a mammalian gene by changing a single AT base pair to a GC base pair. Which of the following methods might she have used to make this change? (Select all that apply.)

A) Site-directed mutagenesis
B) Oligonucleotide-directed mutagenesis
C) CRISPR-Cas9 genome editing followed by nonhomologous end joining (NHEJ)
D) CRISPR-Cas9 genome editing followed by homologous recombination (HR) with a donor template
E) Mutagenesis with radiation