A _ Detects a Change in a Regulated Variable and Sends

A _ detects a change in a regulated variable and sends that information to a(n) which relays signals to a(n) , usually a muscle or a gland.

A) stimulus : receptor : organ system
B) receptor : integrating center : negative feedback control
C) sensor : integrating center : effector
D) receptor : stimulus : regulated variable
E) sensor : effector : integrating center