The ER reportedly contains sensors that monitor the concentration of unfolded or misfolded proteins in the lumen. One proposal suggests that the sensors are normally kept in an inactive state by ______, particularly ______.
A)molecular chaperones, ribosomes
B)proteasomes, BiP
C)molecular chaperones, BiP
D)enzymes, ER
E)molecular chaperones, Rubisco

Question

Quizplus · Accepted Answer

Molecular chaperones, especially BiP, are known to keep ER sensors inactive under normal conditions by binding and stabilizing their conformation. This helps in preventing the sensors from detecting normal levels of unfolded or misfolded proteins, which could trigger the unfolded protein response pathway.

The ER Reportedly Contains Sensors That Monitor the Concentration of Unfolded