During prolonged endurance exercise, why does the liver have difficulty maintaining blood glucose within the normal range?

Question

Quizplus · Accepted Answer

During prolonged endurance exercise, glucose stores in the body are depleted and the liver relies on gluconeogenesis, the production of glucose from non-carbohydrate sources like amino acids and fatty acids. However, the rate of gluconeogenesis is limited and cannot keep up with the demand for glucose, leading to difficulty maintaining blood glucose within the normal range. This is further exacerbated by the decrease in insulin concentration and delay in central nervous system response during exercise, which also contribute to the liver's difficulty in regulating blood glucose levels. Fructose can still be converted to glucose via gluconeogenesis, but this is not the primary limiting factor in maintaining blood glucose during prolonged exercise.

During Prolonged Endurance Exercise, Why Does the Liver Have Difficulty