Question 1

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).
-Patients with aplastic anemia receiving antithymocyte globulin

Accepted Answer

The answer of Match the groups receiving therapy with their...

Question 2

Patients who are severely immunocompromised or immunosuppressed are unable to reject donor cells.

Accepted Answer

Patients who are severely immunocompromised or immunosuppressed have weakened immune systems that are less capable of fighting off foreign cells, including donor cells, making them less likely to reject these cells.

Question 3

The stronger the antigen difference, the more severe the graft-versus-host reaction.

Accepted Answer

The severity of graft-versus-host disease (GVHD) is influenced by the degree of mismatch between the donor's and recipient's human leukocyte antigens (HLAs). A stronger antigen difference typically leads to a more severe immune response, as the donor's immune cells are more likely to recognize the recipient's cells as foreign and attack them.

Question 4

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).
-Children with severe congenital immunodeficiency syndromes involving T lymphocytes

Accepted Answer

Children with severe congenital immunodeficiency syndromes involving T lymphocytes are considered high-risk patients for graft-versus-host disease (GVHD) due to their compromised immune systems, making it harder for their bodies to tolerate and adapt to the transplanted tissue or cells.

Question 5

Immunosuppression is used for the maintenance of the transplant.

Accepted Answer

Immunosuppression is used to prevent the body's immune system from rejecting a transplanted organ, thus it is essential for the maintenance of the transplant.

Question 6

Immunosuppression is used for the suppression of established rejection.

Accepted Answer

The answer of Immunosuppression is used for the suppression of...

Question 7

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD).
-Patients receiving total-body radiation or immunosuppressive therapy for disorders such as lymphoma and acute leukemia

Accepted Answer

The answer of Match the groups receiving therapy with their...

Question 8

Immunosuppression is used for induction (intense immunosuppression in the initial days after transplantation).

Accepted Answer

Immunosuppression is indeed used for induction, which involves intense immunosuppression in the initial days following transplantation to prevent acute rejection during this critical period.

Question 9

Match the HLA typing technique with its basic principle.
-Combination of alloantibody and lymphocyte membrane indicated by cell death allowing penetration of vital dye such as trypan blue.

Accepted Answer

Complement-mediated cytotoxicity involves the combination of alloantibody and lymphocyte membrane, leading to cell death. This process allows penetration of vital dyes such as trypan blue to indicate cell death, which is the basic principle of this technique.

Question 10

Match the HLA typing technique with its basic principle.
-Microparticles coated with purified HLA molecules

Accepted Answer

Microparticles coated with purified HLA molecules are used in techniques like ELISA (Enzyme-Linked Immunosorbent Assay) and flow cytometry, where these particles can be detected and analyzed based on their interaction with specific antibodies. This approach does not involve complement-mediated cytotoxicity, which is a different method that assesses cell death induced by the complement system in the presence of specific antibodies.

Quiz 30: Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD) . -Patients with aplastic anemia receiving antithymocyte globulin

Patients who are severely immunocompromised or immunosuppressed are unable to reject donor cells.

The stronger the antigen difference, the more severe the graft-versus-host reaction.

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD) . -Children with severe congenital immunodeficiency syndromes involving T lymphocytes

Immunosuppression is used for the maintenance of the transplant.

Immunosuppression is used for the suppression of established rejection.

Match the groups receiving therapy with their risk of graft-versus-host disease (GVHD) . -Patients receiving total-body radiation or immunosuppressive therapy for disorders such as lymphoma and acute leukemia

Immunosuppression is used for induction (intense immunosuppression in the initial days after transplantation).

Match the HLA typing technique with its basic principle. -Combination of alloantibody and lymphocyte membrane indicated by cell death allowing penetration of vital dye such as trypan blue.

Match the HLA typing technique with its basic principle. -Microparticles coated with purified HLA molecules