Why hasn't the hormone originally thought to be a potent satiety signal in mice been a miracle cure for obesity in people?

Question

Quizplus · Accepted Answer

While the hormone (leptin) was found to be a potent satiety signal in mice, few humans actually have a deficiency of this hormone, which means that simply increasing leptin levels may not be effective in treating obesity in humans. In fact, many obese individuals have elevated levels of leptin, suggesting that they have developed leptin resistance. Therefore, finding a cure for obesity may require a more complex approach than simply targeting leptin levels.

Why Hasn't the Hormone Originally Thought to Be a Potent